| Nov 6 | Tourn | Michigan State Open | — | — | Jenison Fieldhouse · East Lansing, MI |
| Nov 6 | Tourn | Michigan State Open (Fresh/Soph) | — | — | Jenison Fieldhouse · East Lansing, MI |
| Nov 14 | Non-Conf | vs. CSU Bakersfield | 39–3 | 1-0 | — |
| Nov 19 | Non-Conf | @ Columbia | 34–3 | 2-0 | — |
| Nov 21 | Non-Conf | @ Buffalo | 31–3 | 3-0 | — |
| Dec 3 | Tourn | Cliff Keen Las Vegas Invitational | — | — | Las Vegas Convention Center · Las Vegas, NV |
| Jan 1 | Tourn | Southern Scuffle | — | — | McKenzie Arena Box Office · Chattanooga, TN |
| Jan 7 | Tourn | F&M Lehman Open | — | — | F&M College · Lancaster, PA |
| Jan 9 | Non-Conf | @ Pittsburgh | 29–6 | 4-0 | — |
| Jan 14 | Conf | @ Ohio State | 29–8 | 5-0 | — |
| Jan 21 | Conf | vs. Penn State | 6–29 | 5-1 | — |
| Jan 23 | Conf | vs. Rutgers | 32–8 | 6-1 | — |
| Jan 28 | Conf | vs. Minnesota | 20–14 | 7-1 | — |
| Jan 30 | Conf | @ Maryland | 40–3 | 8-1 | — |
| Feb 4 | Conf | @ Nebraska | 20–13 | 9-1 | — |
| Feb 11 | Conf | @ Indiana | 37–3 | 10-1 | — |
| Feb 13 | Conf | vs. Michigan State | 24–13 | 11-1 | — |
| Feb 20 | Non-Conf | @ Central Michigan | 28–12 | 12-1 | — |
| Mar 5 | Big Ten Champs | Big Ten Championships | 1431st | — | Pinnacle Bank Arena · Lincoln, NE |
| Mar 17 | NCAA Champs | 2022 NCAA Championships | — | — | Little Caesars Arena · Detroit, MI |
