| Nov 6 | Tourn | Michigan State Open | — | — | Jenison Fieldhouse · East Lansing, MI |
| Nov 6 | Tourn | Michigan State Open (Fresh/Soph) | — | — | Jenison Fieldhouse · East Lansing, MI |
| Nov 13 | Conf | vs. Rider | 14–20 | 0-1 | — |
| Nov 20 | Tourn | Lindenwood Open | — | — | Hyland Arena · Saint Charles, MO |
| Nov 20 | Tourn | Lindenwood Open (Fresh/Soph) | — | — | Hyland Arena · Saint Charles, MO |
| Nov 21 | Non-Conf | @ Brown | 33–3 | 1-1 | — |
| Nov 21 | Non-Conf | @ Duke | 17–19 | 1-2 | — |
| Dec 4 | Tourn | Cougar Clash | — | — | Vadalabene Center · Edwardsville, IL |
| Dec 18 | Conf | @ Kent State | 20–12 | 2-2 | — |
| Dec 18 | Non-Conf | vs. Harper | 42–6 | 3-2 | — |
| Dec 18 | Non-Conf | vs. South Dakota State | 9–26 | 3-3 | — |
| Jan 15 | Conf | vs. Ohio | 9–21 | 3-4 | — |
| Jan 21 | Conf | vs. Central Michigan | 6–27 | 3-5 | — |
| Jan 23 | Non-Conf | vs. Oklahoma | 3–28 | 3-6 | — |
| Jan 30 | Non-Conf | @ Cal Poly | 6–22 | 3-7 | — |
| Jan 30 | Non-Conf | vs. Little Rock | 35–6 | 4-7 | — |
| Feb 5 | Conf | vs. Buffalo | 15–17 | 4-8 | — |
| Feb 13 | Non-Conf | vs. Northwestern | 12–22 | 4-9 | — |
| Feb 20 | Conf | vs. SIUE | 35–3 | 5-9 | — |
| Mar 4 | MAC Champs | MAC Wrestling Championships | 933rd | — | Ohio University Convocation Center · Athens, OH |
| Mar 17 | NCAA Champs | 2022 NCAA Championships | — | — | Little Caesars Arena · Detroit, MI |
