| Nov 13 | Tourn | Bison Open | — | — | Sanford Health Athletic Complex · Fargo, ND |
| Nov 20 | Non-Conf | vs. Oklahoma State | 10–23 | 0-1 | — |
| Nov 21 | Tourn | Warren Williamson Daktronics Open | — | — | Stanley J Marshall Center · Brookings, SD |
| Nov 28 | Non-Conf | vs. South Dakota State | 27–13 | 1-1 | — |
| Dec 3 | Tourn | Cliff Keen Las Vegas Invitational | — | — | Las Vegas Convention Center · Las Vegas, NV |
| Jan 1 | Tourn | Southern Scuffle | — | — | McKenzie Arena Box Office · Chattanooga, TN |
| Jan 7 | Conf | @ Iowa | 10–22 | 1-2 | — |
| Jan 9 | Conf | vs. Northwestern | 31–9 | 2-2 | — |
| Jan 14 | Conf | vs. Nebraska | 19–13 | 3-2 | — |
| Jan 16 | Conf | vs. Wisconsin | 15–21 | 3-3 | — |
| Jan 28 | Conf | @ Michigan | 14–20 | 3-4 | — |
| Feb 4 | Conf | @ Illinois | 22–12 | 4-4 | — |
| Feb 6 | Conf | @ Purdue | 14–18 | 4-5 | — |
| Feb 11 | Conf | vs. Ohio State | 14–24 | 4-6 | — |
| Feb 20 | Tourn | ISU Last Chance Open | — | — | Hilton Coliseum · Ames, IA |
| Mar 5 | Big Ten Champs | Big Ten Championships | 78.56th | — | Pinnacle Bank Arena · Lincoln, NE |
| Mar 17 | NCAA Champs | 2022 NCAA Championships | — | — | Little Caesars Arena · Detroit, MI |
