| Nov 6 | Tourn | Michigan State Open | — | — | Jenison Fieldhouse · East Lansing, MI |
| Nov 6 | Tourn | Michigan State Open (Fresh/Soph) | — | — | Jenison Fieldhouse · East Lansing, MI |
| Nov 20 | Tourn | Lindenwood Open | — | — | Hyland Arena · Saint Charles, MO |
| Nov 20 | Tourn | Lindenwood Open (Fresh/Soph) | — | — | Hyland Arena · Saint Charles, MO |
| Nov 20 | Tourn | Navy Classic | — | — | Naval Academy · Annapolis, MD |
| Dec 2 | Non-Conf | @ Lock Haven | 20–17 | 1-0 | — |
| Dec 3 | Non-Conf | @ Bucknell | 23–10 | 2-0 | — |
| Dec 11 | Non-Conf | @ Gardner-Webb | 29–12 | 3-0 | — |
| Dec 18 | Non-Conf | @ Olivet | 37–9 | 4-0 | — |
| Jan 1 | Tourn | Southern Scuffle | — | — | McKenzie Arena Box Office · Chattanooga, TN |
| Jan 8 | Conf | vs. Ohio State | 14–27 | 4-1 | — |
| Jan 15 | Conf | @ Purdue | 16–16 | 4-1-1 | — |
| Jan 17 | Conf | @ Indiana | 17–15 | 5-1-1 | — |
| Jan 21 | Conf | vs. Rutgers | 20–17 | 6-1-1 | — |
| Jan 23 | Conf | vs. Penn State | 9–28 | 6-2-1 | — |
| Feb 4 | Conf | @ Maryland | 29–6 | 7-2-1 | — |
| Feb 11 | Conf | vs. Northwestern | 16–24 | 7-3-1 | — |
| Feb 13 | Conf | @ Michigan | 13–24 | 7-4-1 | — |
| Feb 18 | Non-Conf | vs. Central Michigan | 19–18 | 8-4-1 | — |
| Mar 5 | Big Ten Champs | Big Ten Championships | 3312th | — | Pinnacle Bank Arena · Lincoln, NE |
| Mar 17 | NCAA Champs | 2022 NCAA Championships | — | — | Little Caesars Arena · Detroit, MI |
